Endocrine Abstracts

Aldosterone and glucocorticoids stimulate sodium transport by the renal tubule, which is important for blood pressure homeostasis. Corticosteroid excess and/or abnormal steroid hormone activity within the kidney can cause hypertension. Circulatory and urinary steroid concentrations can be measured routinely but steroid concentrations at a tissue and cellular level are largely unknown, and the kidney remains a “black box”. Mass spectrometry imaging (MSI) permits local...

The human endometrium is a complex multicellular tissue the prime function of which is to provide a receptive environment during a fertile cycle. The tissue responds to steroid hormones exhibiting dynamic cyclical regeneration, angiogenesis, differentiation (decidualisation) and inflammation. In the absence of an embryo the inner surface is shed and repaired without scarring (menstruation). The endometrium exhitbits spatial and temporal expression of androgen receptors (AR) in...

Objective: Parathyroidectomy (PTx) improves quality of life (QoL) in patients with primary hyperparathyroidism (PHPT). Whether this effect is modified according to the patients’ age is unknown. The aim of this study was to evaluate the impact of age on the effect of PTx on QoL and frailty in patients with PHPT, six months post-PTx. Methods: This was a prospective cohort study, including patients with PHPT, admitted from January 2016 to December 2019...

Background: Levothyroxine (LT4-Rx) is one of the most prescribed drugs worldwide and the vast majority of patients receive long-term treatment. However, in a recent study of 291 subjects we found that 60% of this cohort were euthyroid two months after LT4-Rx discontinuation1.Aim of the study: A prospective clinical cohort follow-up study was carried out. In 688 subjects (82% females) aged 48.01±15.96 (range 17-84years) with 8.59±6.98...

Introduction: Obesity is rising worldwide and the number overweight or obese patients with type 1 diabetes mellitus (T1DM) is increased and eating habits (EH) and physical activity (PA) play an important role on glycemic control and weight gain. The aim of the present study was to examine the EH and the exercise level in patients with T1DM and their relation to body weight.Methods: 126 patients with T1DM (55/126 males, 71/126 females) attending our outpa...

Introduction: Ephrin receptors (EPHs) compose the largest known subfamily of receptors tyrosine kinases and are bound and interact with EPHs-interacting proteins (Ephrins). They have a role in tumor growth, invasion, angiogenesis and metastasis of several neoplasms. Aim of the study was to investigate the expression of EPH-A4, -A5, -B2 and -B5 in pituitary lesions. Material and Methods: Our study group consisted of 18 patients (9 males with median age 54...

Background: Levothyroxine (LT4Rx) is one of the most prescribed drugs worldwide the vast majority of patients receive long-term treatment. However, in a recent study of 291 subjects, it was found that 60% were euthyroid 2 months after LT4-Rx discontinuation1.Aim of the study: A prospective clinical cohort follow-up study was carried out. In 688 subjects (82% females) aged 48.01±15.96 (range 17-84years) with 8.59±6.98 years on LT4Rx witho...

Blood pressure homeostasis is regulated via renal sodium reabsorption by aldosterone and glucocorticoids, although the role of glucocorticoids is less clear. High-salt diets lead to suppression of aldosterone in plasma, but changes in available ligands for the mineralocorticoid and glucocorticoid receptors in kidney subregions are unknown. Hypothetically, high-salt intake modifies aldosterone and corticosterone amounts in specific kidney subregions. Kidney cryosections from ma...

Background: Adipose tissue exhibits an altered adipokine secretion profile in obesity which is pro-inflammatory and relates to higher risk of cardio-metabolic diseases. Asprosin is a novel pleiotropic adipokine with orexigenic and glucogenic effects which is secreted in response to fasting. Elevated circulating asprosin levels have been shown in obesity and type 2 diabetes, as well as in other cardio-metabolic diseases. Furthermore, in vitro studies have reported pro-...

Chronic stress is a pervasive concern in the modern society. A long-term hyper activation of the hypothalamic-pituitary-adrenal (HPA) axis leads to elevated amounts of stress hormones [e.g. ACTH and glucocorticoids (GCs)]. This can incur maladaptation that eventually contributes to mental illness, cardiovascular dysfunctions, diabetes, cancer and autoimmune diseases. Emerging key players for stress adaptation of the HPA axis are stem/progenitor cell populations. In this study,...